[Stress and the thyroid gland]

Biomed Khim. Jul-Aug 2010;56(4):443-56.
[Article in Russian]


The review highlights the effects of acute and chronic stress on thyroid metabolism. Special attention is paid to the influence of stress and the direct effects of glucocorticoids on the thyroid status, the activities of thyrocyte iodine uptake, oxidation and organification as well as peripheral metabolism of thyroid hormones (deposition and transport of thyroid hormones, deiodinase activities in different tissues). The role of stress in the development of thyroid pathology is analysed and characteristic features of thyroid function alterations during impaired functioning of the pitiutary-adrenal system are established. The mechanisms of the stress-induced impairments in thyroid functions are of interest for further research, taking into consideration serious consequences of thyroid deficiency for the body, even in subclinical thyroid insufficiency.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Chronic Disease
  • Glucocorticoids / physiology
  • Humans
  • Hypothalamo-Hypophyseal System / physiopathology
  • Iodides / metabolism
  • Pituitary-Adrenal System / physiopathology
  • Receptors, Thyroid Hormone / physiology
  • Stress, Physiological*
  • Stress, Psychological / complications*
  • Stress, Psychological / metabolism
  • Stress, Psychological / physiopathology
  • Thyroid Diseases / etiology*
  • Thyroid Diseases / metabolism
  • Thyroid Diseases / physiopathology
  • Thyroid Gland / metabolism*
  • Thyroid Gland / physiopathology*
  • Thyroid Hormones / physiology


  • Glucocorticoids
  • Iodides
  • Receptors, Thyroid Hormone
  • Thyroid Hormones