Aspergillus nidulans asexual development: making the most of cellular modules

Trends Microbiol. 2010 Dec;18(12):569-76. doi: 10.1016/j.tim.2010.09.007. Epub 2010 Oct 28.


Asexual development in Aspergillus nidulans begins in superficial hyphae as the programmed emergence of successive pseudohyphal modules, collectively known as the conidiophore, and is completed by a layer of specialized cells (phialides) giving rise to chains of aerial spores. A discrete number of regulatory factors present in hyphae play different stage-specific roles in pseudohyphal modules, depending on their cellular localization and protein-protein interactions. Their multiple roles include the timely activation of a sporulation-specific pathway that governs phialide and spore formation. Such functional versatility provides for a new outlook on morphogenetic change and the ways we should study it.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aspergillus nidulans / growth & development*
  • Aspergillus nidulans / physiology*
  • Fungal Proteins / physiology
  • Gene Expression Regulation, Fungal
  • Hyphae / physiology
  • Reproduction, Asexual*
  • Spores, Fungal / growth & development


  • Fungal Proteins