Genome-wide identification of genes that play a role in boron stress response in yeast

Genomics. 2011 Feb;97(2):106-11. doi: 10.1016/j.ygeno.2010.10.006. Epub 2010 Oct 28.


Boron is an essential micronutrient for plants and it is either necessary or beneficial for animals. Studies identified only few genes related to boron metabolism thus far and details of how boron is imported into cells and used in cell metabolism are largely unknown. In order to identify genes that play roles in boron metabolism, we screened the entire set of yeast haploid deletion mutants and identified 6 mutants that were resistant to toxic levels of boron, and 21 mutants that were highly sensitive to boron treatment. Furthermore, we performed a proteomic approach to identify additional proteins that are significantly up-regulated by boron treatment. Our results revealed many genes and pathways related to boron stress response and suggest a possible link between boron toxicity and translational control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Boron / metabolism*
  • Boron / pharmacology
  • Gene Expression Profiling
  • Genome-Wide Association Study*
  • Haploidy
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / genetics*
  • Sequence Deletion
  • Stress, Physiological / genetics*
  • Up-Regulation


  • Saccharomyces cerevisiae Proteins
  • Boron