Impact of Viral Load of Hepatitis C on the Incidence of Hepatocellular Carcinoma: A Population-Based Cohort Study (JPHC Study)

Cancer Lett. 2011 Jan 28;300(2):173-9. doi: 10.1016/j.canlet.2010.10.002. Epub 2010 Oct 29.


Impact of viral load of HCV on the incidence of hepatocellular carcinoma was investigated using a population-based cohort consisting of 20,794 Japanese. A total of 114 newly arising cases of hepatocellular carcinoma were diagnosed during follow-up. Compared to the hepatitis virus-negative group, the hazard ratio (HR) of developing hepatocellular carcinoma was 35.8-fold higher in HCV monoinfection (95% confidence interval [CI], 20.7-62.7). A titer-dependent increase in risk was not identified. The risk was 3.86-fold higher (CI; 1.73-8.62) for genotype 1 than genotype 2. Our findings suggest that HCV viremia strongly influences the occurrence of hepatocellular carcinoma without titer-dependence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular / blood
  • Carcinoma, Hepatocellular / epidemiology
  • Carcinoma, Hepatocellular / virology*
  • Cohort Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hepatitis C / complications*
  • Hepatitis C / genetics
  • Hepatitis C / virology
  • Humans
  • Incidence
  • Japan
  • Liver Neoplasms / blood
  • Liver Neoplasms / epidemiology
  • Liver Neoplasms / virology*
  • Male
  • Middle Aged
  • Viral Load*