Synthesis of potent, substituted carbazoles as selective androgen receptor modulators (SARMs)

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7516-20. doi: 10.1016/j.bmcl.2010.09.140. Epub 2010 Oct 7.


The synthesis and in vitro binding affinity for a novel series of potent androgen receptor modulators is described. One of the more potent compounds (17, RAD35010) was further characterized in vivo where it restored levator ani weight in castrated male rats to near sham level while having no significant effect on prostate weight.

MeSH terms

  • Administration, Oral
  • Animals
  • Carbazoles / chemical synthesis
  • Carbazoles / chemistry*
  • Carbazoles / pharmacology
  • Male
  • Prostate / drug effects
  • Rats
  • Receptors, Androgen / chemistry*
  • Receptors, Androgen / metabolism


  • Carbazoles
  • Receptors, Androgen