dnaX36 Mutator of Escherichia coli: effects of the {tau} subunit of the DNA polymerase III holoenzyme on chromosomal DNA replication fidelity

J Bacteriol. 2011 Jan;193(1):296-300. doi: 10.1128/JB.01191-10. Epub 2010 Oct 29.


The Escherichia coli dnaX36 mutant displays a mutator effect, reflecting a fidelity function of the dnaX-encoded τ subunit of the DNA polymerase III (Pol III) holoenzyme. We have shown that this fidelity function (i) applies to both leading- and lagging-strand synthesis, (ii) is independent of Pol IV, and (iii) is limited by Pol II.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Bacterial
  • DNA Polymerase III / genetics
  • DNA Polymerase III / metabolism*
  • DNA Replication / physiology*
  • Escherichia coli / classification
  • Escherichia coli / genetics*
  • Escherichia coli / metabolism*
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism*
  • Gene Expression Regulation, Bacterial / physiology
  • Mutation
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • Escherichia coli Proteins
  • Transcription Factors
  • transcription factor tau
  • DNA Polymerase III