Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry

Chem Commun (Camb). 2010 Dec 28;46(48):9119-21. doi: 10.1039/c0cc03420g. Epub 2010 Oct 29.

Abstract

Statistical correlation of mass spectrum peak broadening with product dispersity in protein conjugation reactions allows more detailed characterization of putative therapeutic conjugates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Carbohydrates / analysis
  • Data Interpretation, Statistical
  • Glycoproteins / chemistry*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*

Substances

  • Carbohydrates
  • Glycoproteins