CO2 and diode laser for excisional biopsies of oral mucosal lesions. A pilot study evaluating clinical and histopathological parameters

Schweiz Monatsschr Zahnmed. 2010;120(8):664-71.


Purpose: The present pilot study evaluates the histopathological characteristics and suitability of CO2 and diode lasers for performing excisional biopsies in the buccal mucosa with special emphasis on the extent of the thermal damage zone created.

Patients and methods: 15 patients agreed to undergo surgical removal of their fibrous hyperplasias with a laser. These patients were randomly assigned to one diode or two CO2 laser groups. The CO2 laser was used in a continuous wave mode (cw) with a power of 5 W (Watts), and in a pulsed char-free mode (cf). Power settings for the diode laser were 5.12 W in a pulsed mode. The thermal damage zone of the three lasers and intraoperative and postoperative complications were assessed and compared.

Results: The collateral thermal damage zone on the borders of the excisional biopsies was significantly smaller with the CO, laser for both settings tested compared to the diode laser regarding values in pm or histopathological index scores. The only intraoperative complication encountered was bleeding, which had to be controlled with electrocauterization. No postoperative complications occurred in any of the three groups.

Conclusions: The CO2 laser seems to be appropriate for excisional biopsies of benign oral mucosal lesions. The CO2 laser offers clear advantages in terms of smaller thermal damage zones over the diode laser. More study participants are needed to demonstrate potential differences between the two different CO2 laser settings tested.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biopsy / methods
  • Blood Loss, Surgical
  • Burns / etiology
  • Chi-Square Distribution
  • Electrocoagulation
  • Female
  • Humans
  • Hyperplasia / pathology
  • Hyperplasia / surgery
  • Laser Therapy / instrumentation
  • Laser Therapy / methods*
  • Lasers, Gas*
  • Lasers, Semiconductor*
  • Male
  • Middle Aged
  • Mouth Mucosa / injuries
  • Mouth Mucosa / pathology*
  • Mouth Mucosa / surgery*
  • Pilot Projects
  • Statistics, Nonparametric