Chromatography in a single metal-organic framework (MOF) crystal

J Am Chem Soc. 2010 Nov 24;132(46):16358-61. doi: 10.1021/ja1074322. Epub 2010 Nov 1.


Millimeter-sized single MOF-5 crystals are used as "chromatographic columns" to effectively separate mixtures of organic dyes. Remarkably, owing to the nanoscopic pore dimensions and the molecular-level interactions between the migrating molecules and the MOF scaffold, the separations occur over a distance of only a few hundred micrometers which is unambiguously confirmed by fluorescence confocal microscopy.