Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study

Nature. 1978 Aug 24;274(5673):756-61. doi: 10.1038/274756a0.


Results from a prospective sero-epidemiological study initiated in Uganda in 1971 indicate that children with high antibody titres to Epstein-Barr virus structural antigens are at high risk of developing Burkitt's lymphoma. These findings strongly support a causal relationship between the Epstein-Barr virus and Burkitt's lymphoma but suggest that the oncogenic potential of the virus is realised only in exceptional circumstances.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Antibodies, Viral / analysis
  • Burkitt Lymphoma / etiology*
  • Burkitt Lymphoma / microbiology
  • Child
  • Child, Preschool
  • Cocarcinogenesis
  • Female
  • Herpesvirus 4, Human* / immunology
  • Humans
  • Malaria / complications
  • Male
  • Uganda


  • Antibodies, Viral