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. 2011 May;21(3):321-9.
doi: 10.1111/j.1750-3639.2010.00449.x. Epub 2010 Nov 11.

Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease

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Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease

Zareen Amtul et al. Brain Pathol. .

Erratum in

  • Erratum.
    Brain Pathol. 2017 Sep;27(5):702-703. doi: 10.1111/bpa.12512. Brain Pathol. 2017. PMID: 28805008 No abstract available.

Abstract

Several lines of evidence support protective as well as deleterious effects of oleic acid (OA) on Alzheimer's disease (AD) and other neurological disorders; however, the bases of these effects are unclear. Our investigation demonstrates that amyloid precursor protein (APP) 695 transfected Cos-7 cells supplemented with OA have reduced secreted amyloid-beta (Aβ) levels. An early-onset AD transgenic mouse model expressing the double-mutant form of human APP, Swedish (K670N/M671L) and Indiana (V717F), corroborated our in vitro findings when they were fed a high-protein, low-fat (18% reduction), cholesterol-free diet enriched with OA. These mice exhibited an increase in Aβ40/Aβ42 ratio, reduced levels of beta-site APP cleaving enzyme (BACE) and reduced presenilin levels along with reduced amyloid plaques in the brain. The decrease in BACE levels was accompanied by increased levels of a non-amyloidogenic soluble form of APP (sAPPα). Furthermore, the low-fat/+OA diet resulted in an augmentation of insulin-degrading enzyme and insulin-like growth factor-II. These results suggest that OA supplementation and cholesterol intake restriction in a mouse model of AD reduce AD-type neuropathology.

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