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Review
. 2011 Jan;118(2):175-86.
doi: 10.1111/j.1471-0528.2010.02749.x. Epub 2010 Oct 13.

Parvovirus B19 Infection in Human Pregnancy

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Free PMC article
Review

Parvovirus B19 Infection in Human Pregnancy

R F Lamont et al. BJOG. .
Free PMC article

Abstract

Human parvovirus B19 infection is widespread. Approximately 30-50% of pregnant women are nonimmune, and vertical transmission is common following maternal infection in pregnancy. Fetal infection may be associated with a normal outcome, but fetal death may also occur without ultrasound evidence of infectious sequelae. B19 infection should be considered in any case of nonimmune hydrops. Diagnosis is mainly through serology and polymerase chain reaction. Surveillance requires sequential ultrasound and Doppler screening for signs of fetal anaemia, heart failure and hydrops. Immunoglobulins, antiviral and vaccination are not yet available, but intrauterine transfusion in selected cases can be life saving.

Figures

Figure 1
Figure 1
Investigation for parvovirus B19 of pregnant women exposed to rash illness From the 2000 Public Health Laboratory Service Working Party on “Rash Diagnosis in “Pregnancy and Rubella Screening” subsequently reported
Figure 2
Figure 2
Management of confirmed parvovirus B19 infection in pregnancy From the 2000 Public Health Laboratory Service Working Party on “Rash Diagnosis in “Pregnancy and Rubella Screening” subsequently reported

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