Stem cells and osteoporosis therapy

Steven L Teitelbaum

doi:10.1016/j.stem.2010.10.004

Stem cells and osteoporosis therapy

Cell Stem Cell. 2010 Nov 5;7(5):553-4. doi: 10.1016/j.stem.2010.10.004.

Author

Steven L Teitelbaum¹

Affiliation

¹ Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA. teitelbs@wustl.edu

PMID: 21040895
DOI: 10.1016/j.stem.2010.10.004

Abstract

Skeletal remodeling requires recruitment of osteoblast precursors, in the form of MSCs, to the bone surface. In this issue of Cell Stem Cell, Wu et al. (2010) demonstrate that this event is mediated by osteoclastic mobilization of active transforming growth factor β1, which is inhibited by a common antiosteoporosis drug.

MeSH terms

Alendronate / pharmacology
Bone Density Conservation Agents / pharmacology
Humans
Mesenchymal Stem Cells* / physiology
Osteoblasts / physiology*
Osteoclasts / drug effects*
Osteoporosis / therapy*
Transforming Growth Factor beta1 / antagonists & inhibitors*

Substances

Bone Density Conservation Agents
Transforming Growth Factor beta1
Alendronate