Functional neural networks of time perception: challenge and opportunity for schizophrenia research

Schizophr Res. 2011 Feb;125(2-3):129-35. doi: 10.1016/j.schres.2010.10.003. Epub 2010 Nov 1.


With the double objective of searching for a physiological brain circuit concerned with time estimation and establishing whether this circuit is dysfunctional in schizophrenia patients, we carried out an activation likelihood estimate (ALE) meta-analysis of published functional neuroimaging studies. Our results reproduce the previous finding of a neurophysiological cortico-cerebellar-thalamic circuit related with time estimation in healthy individuals. In schizophrenia patients, the analysis indicates significantly lower activation of most right hemisphere regions of the circuit, suggesting that it may be subject to a pattern of disconnectivity. The ALE-meta-analysis approach is useful and further studies could elucidate how the timing circuit is connected with other cognitive tasks.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Attention / physiology
  • Brain / physiopathology*
  • Brain Mapping
  • Cognition / physiology
  • Dominance, Cerebral / physiology
  • Electroencephalography
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging*
  • Magnetoencephalography
  • Memory, Short-Term / physiology
  • Nerve Net / physiopathology*
  • Positron-Emission Tomography*
  • Schizophrenia / diagnosis
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Signal Processing, Computer-Assisted
  • Time Perception / physiology*