Management of sepsis in neutropenic patients: guidelines from the infectious diseases working party of the German Society of Hematology and Oncology

O Penack; D Buchheidt; M Christopeit; M von Lilienfeld-Toal; G Massenkeil; M Hentrich; H Salwender; H-H Wolf; H Ostermann

doi:10.1093/annonc/mdq442

Management of sepsis in neutropenic patients: guidelines from the infectious diseases working party of the German Society of Hematology and Oncology

Ann Oncol. 2011 May;22(5):1019-1029. doi: 10.1093/annonc/mdq442. Epub 2010 Nov 1.

Authors

O Penack¹, D Buchheidt², M Christopeit³, M von Lilienfeld-Toal⁴, G Massenkeil⁵, M Hentrich⁶, H Salwender⁷, H-H Wolf³, H Ostermann⁸

Affiliations

¹ Department of Hematology and Oncology, Charité Campus Benjamin Franklin, Berlin. Electronic address: olaf.penack@charite.de.
² Third Department of Internal Medicine, University Medical Centre Mannheim, University of Heidelberg, Heidelberg.
³ Department of Internal Medicine IV, Oncology and Hematology, University Hospital of Martin-Luther-University, Halle (Saale).
⁴ Department of Haematology and Oncology, University of Bonn, Bonn.
⁵ Second Department of Internal Medicine, Hospital Gütersloh, Gütersloh.
⁶ Department of Hematology, Oncology and Palliative Care, Harlaching Hospital, Munich.
⁷ Department of Haematology and Oncology, Asklepios Hospital Altona, Hamburg.
⁸ Third Department of Internal Medicine, Ludwig-Maximilians University, Munich, Germany.

PMID: 21041377
DOI: 10.1093/annonc/mdq442

Abstract

Sepsis is a leading cause of mortality in neutropenic cancer patients. Early initiation of effective causative therapy as well as intensive adjunctive therapy is mandatory to improve outcome. We give recommendations for the management of adults with neutropenia and sepsis. The guidelines are written for clinicians involved in care of cancer patients and focus on pathophysiology, diagnosis and treatment of sepsis during neutropenia.

Publication types

Consensus Development Conference
Practice Guideline

MeSH terms

Adult
Anti-Infective Agents / therapeutic use*
Anticoagulants / therapeutic use
Antineoplastic Agents / adverse effects
Cardiovascular Diseases / etiology
Cardiovascular Diseases / therapy
Disease Management
Glucose Metabolism Disorders / etiology
Glucose Metabolism Disorders / therapy
Humans
Neoplasms / complications
Neoplasms / drug therapy
Neutropenia / chemically induced
Neutropenia / complications
Neutropenia / therapy*
Renal Insufficiency / etiology
Renal Insufficiency / therapy
Respiratory Insufficiency / etiology
Respiratory Insufficiency / therapy
Sepsis / diagnosis
Sepsis / drug therapy*
Sepsis / etiology
Sepsis / microbiology

Substances

Anti-Infective Agents
Anticoagulants
Antineoplastic Agents