Revisiting caveolin trafficking: the end of the caveosome

J Cell Biol. 2010 Nov 1;191(3):439-41. doi: 10.1083/jcb.201009093.


In this issue, a study by Hayer et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003086) provides insights into the trafficking of caveolins, the major membrane proteins of caveolae. As well as providing evidence for ubiquitin-mediated endosomal sorting and degradation of caveolin in multivesicular bodies (MVBs), the new findings question the existence of a unique organelle proposed nine years ago, the caveosome.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caveolae / metabolism*
  • Caveolins / metabolism*
  • Endosomes / metabolism
  • Humans
  • Multivesicular Bodies / metabolism
  • Protein Transport
  • Ubiquitin / metabolism


  • Caveolins
  • Ubiquitin