Platelet-derived Growth Factor and its Receptor: Structure and Roles in Normal Growth and Pathology

Platelets. 1993;4(6):304-15. doi: 10.3109/09537109309013233.


Platelet-derived growth factor (PDGF) is a pleotropic mitogen involved in several normal processes and pathological settings which include embryonal development, wound healing, atherosclerosis and neoplasia. We have reviewed the literature on the structure, function and regulation of PDGF and its receptors, and the roles played by PDGF in these settings.