Feasibility of incorporating genomic knowledge into electronic medical records for pharmacogenomic clinical decision support

BMC Bioinformatics. 2010 Oct 28;11 Suppl 9(Suppl 9):S10. doi: 10.1186/1471-2105-11-S9-S10.

Abstract

In pursuing personalized medicine, pharmacogenomic (PGx) knowledge may help guide prescribing drugs based on a person's genotype. Here we evaluate the feasibility of incorporating PGx knowledge, combined with clinical data, to support clinical decision-making by: 1) analyzing clinically relevant knowledge contained in PGx knowledge resources; 2) evaluating the feasibility of a rule-based framework to support formal representation of clinically relevant knowledge contained in PGx knowledge resources; and, 3) evaluating the ability of an electronic medical record/electronic health record (EMR/EHR) to provide computable forms of clinical data needed for PGx clinical decision support. Findings suggest that the PharmGKB is a good source for PGx knowledge to supplement information contained in FDA approved drug labels. Furthermore, we found that with supporting knowledge (e.g. IF age <18 THEN patient is a child), sufficient clinical data exists in University of Washington's EMR systems to support 50% of PGx knowledge contained in drug labels that could be expressed as rules.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Databases, Factual
  • Decision Support Systems, Clinical*
  • Electronic Health Records*
  • Genome, Human
  • Humans
  • Pharmacogenetics / methods*
  • Precision Medicine / methods