Abstract
Methotrexate remains the most widely used agent for the treatment of rheumatoid arthritis and other chronic inflammatory diseases. Although introduced as a chemotherapeutic agent for the treatment of malignancies, it is clear that, in the doses used, the mechanism of action in the suppression of inflammation differs from simply suppression of purine and pyrimidine metabolism, resulting in inhibition of proliferation. Here we review the proposed mechanisms of action of methotrexate.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine / metabolism
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Animals
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Anti-Inflammatory Agents / therapeutic use*
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Antirheumatic Agents / therapeutic use*
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Arthritis, Rheumatoid / drug therapy*
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Arthritis, Rheumatoid / immunology
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Arthritis, Rheumatoid / metabolism
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Humans
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Inflammation Mediators / metabolism
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Methotrexate / therapeutic use*
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Treatment Outcome
Substances
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Anti-Inflammatory Agents
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Antirheumatic Agents
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Inflammation Mediators
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Adenosine
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Methotrexate