Side effects and management of side effects of methotrexate in rheumatoid arthritis

Clin Exp Rheumatol. 2010 Sep-Oct;28(5 Suppl 61):S95-101. Epub 2010 Oct 28.


Low-dose methotrexate (MTX) remains the first-line treatment option among the disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. However, diverse side effects are the major reason for MTX withdrawal and change of treatment. The following article reviews the published data on general and organ-specific side effects and outlines the current recommendations addressing prevention and management of MTX-associated adverse effects.

Publication types

  • Review

MeSH terms

  • Antirheumatic Agents / administration & dosage
  • Antirheumatic Agents / adverse effects*
  • Arthritis, Rheumatoid / drug therapy*
  • Drug Monitoring
  • Drug Therapy, Combination
  • Humans
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects*
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome


  • Antirheumatic Agents
  • Methotrexate