Metabolic benefits of resistance training and fast glycolytic skeletal muscle

Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E3-10. doi: 10.1152/ajpendo.00512.2010. Epub 2010 Nov 2.


Skeletal muscle exhibits remarkable plasticity with respect to its metabolic properties. Recent work has shown that interventions such as resistance training, genetic alterations and pharmacological strategies that increase muscle mass and glycolytic capacity, and not necessarily oxidative competence, can improve body composition and systemic metabolism. We review here recent advances in our understanding of the signaling and transcriptional regulatory pathways of this strategy and review new evidence obtained from mice and humans that supports the notion that increasing muscle mass and glycolytic capacity may effectively counter insulin resistance and type 2 diabetes mellitus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Composition
  • Diabetes Mellitus, Type 2 / therapy
  • Glycolysis
  • Humans
  • Insulin Resistance
  • Muscle Fibers, Fast-Twitch / metabolism*
  • Muscular Atrophy / prevention & control
  • Myostatin / physiology
  • Resistance Training*
  • Signal Transduction


  • Myostatin