Functions of Nogo proteins and their receptors in the nervous system

Nat Rev Neurosci. 2010 Dec;11(12):799-811. doi: 10.1038/nrn2936. Epub 2010 Nov 3.


The membrane protein Nogo-A was initially characterized as a CNS-specific inhibitor of axonal regeneration. Recent studies have uncovered regulatory roles of Nogo proteins and their receptors--in precursor migration, neurite growth and branching in the developing nervous system--as well as a growth-restricting function during CNS maturation. The function of Nogo in the adult CNS is now understood to be that of a negative regulator of neuronal growth, leading to stabilization of the CNS wiring at the expense of extensive plastic rearrangements and regeneration after injury. In addition, Nogo proteins interact with various intracellular components and may have roles in the regulation of endoplasmic reticulum (ER) structure, processing of amyloid precursor protein and cell survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Endoplasmic Reticulum / physiology
  • GPI-Linked Proteins / physiology
  • Gene Expression Regulation, Developmental
  • Humans
  • Models, Biological
  • Myelin Proteins / physiology*
  • Nervous System / metabolism*
  • Nervous System / ultrastructure
  • Nervous System Malformations / metabolism
  • Nervous System Malformations / pathology
  • Nervous System Malformations / physiopathology
  • Neurons / physiology
  • Nogo Proteins
  • Nogo Receptor 1
  • Receptors, Cell Surface / physiology*
  • Signal Transduction / physiology


  • Amyloid beta-Protein Precursor
  • GPI-Linked Proteins
  • Myelin Proteins
  • Nogo Proteins
  • Nogo Receptor 1
  • RTN4 protein, human
  • RTN4R protein, human
  • Receptors, Cell Surface