A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides

J Org Chem. 2010 Dec 3;75(23):8330-2. doi: 10.1021/jo1018798. Epub 2010 Nov 3.

Abstract

A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd(2)(dba)(3) and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cross-Linking Reagents
  • Hydrocarbons, Chlorinated / chemistry*
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry*

Substances

  • Cross-Linking Reagents
  • Hydrocarbons, Chlorinated
  • Indicators and Reagents
  • Organometallic Compounds