The RecQ DNA helicases in DNA repair

Annu Rev Genet. 2010;44:393-417. doi: 10.1146/annurev-genet-102209-163602.

Abstract

The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / enzymology*
  • DNA Repair*
  • Disease / genetics
  • Genomic Instability
  • Humans
  • RecQ Helicases / chemistry
  • RecQ Helicases / genetics
  • RecQ Helicases / metabolism*

Substances

  • RecQ Helicases