Deep vein thrombosis prophylaxis in hospitalized medical patients: current recommendations, general rates of implementation, and initiatives for improvement

Clin Chest Med. 2010 Dec;31(4):675-89. doi: 10.1016/j.ccm.2010.07.005.


Venous thromboembolism (VTE), which encompasses deep vein thrombosis and pulmonary embolism, is a leading cause of preventable morbidity and mortality following hospitalization. In the last decade, investigators have used randomized controlled trials to assess the efficacy and safety of various methods of VTE prevention for more than 20,000 medical patients. Identifying medical patients at risk for VTE and providing effective prophylaxis is now an important health care priority to reduce the burden of this morbid and sometimes fatal disease. Pharmacologic prophylaxis is the mainstay of VTE prevention. It is effective, safe, and cost effective. Multiple scientific guidelines support VTE prophylaxis in medical patients. Regulatory and accreditation agencies have mandated that hospitals use formalized systems to assess VTE risk and provide clinically appropriate prophylaxis measures to patients at risk.

Publication types

  • Review

MeSH terms

  • Anticoagulants / administration & dosage*
  • Anticoagulants / therapeutic use
  • Hospitalization
  • Humans
  • Practice Guidelines as Topic / standards
  • Pulmonary Embolism / prevention & control*
  • Quality Assurance, Health Care / methods*
  • Risk Factors
  • Risk Management
  • Venous Thromboembolism / prevention & control*
  • Venous Thrombosis / prevention & control*


  • Anticoagulants