The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern

EMBO J. 1990 Jan;9(1):207-16.

Abstract

We have identified a Drosophila zinc-finger protein, which binds to a number of sites in the transcriptional control regions of the pair-rule gene fushi-tarazu (ftz). The expression pattern of the mRNA that encodes this protein is essentially complementary to that of ftz both prior to blastoderm formation and during germband extension. We propose that the protein may function by repressing inappropriate segmentation gene transcription during embryogenesis. The gene encoding this ftz promoter-binding protein has been named tramtrack (ttk).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Cloning, Molecular
  • DNA / genetics
  • DNA / metabolism
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics*
  • Enhancer Elements, Genetic
  • Gene Expression*
  • Metalloproteins / genetics*
  • Metalloproteins / metabolism
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • Regulatory Sequences, Nucleic Acid
  • Transcription, Genetic*
  • Zygote / metabolism

Substances

  • DNA-Binding Proteins
  • Metalloproteins
  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/X17121