Abstract
Two new phenolic amides, pharnilatins A (1) and B (2), were isolated from the seeds of Pharbitis nil. These new compounds possess a p-coumaroyl unit with a structurally unique side chain, (2S,3S)-2,3-dihydroxyputrescine. The chemical structures and absolute stereochemistries of the new compounds were determined on the basis of spectroscopic analyses including 1D- and 2D-NMR experiments and chemical reactions. Compounds 1 and 2 exhibited cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cells. However, none of the compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated microglia cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry
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Amides / isolation & purification
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Amides / pharmacology
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line
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Cell Line, Tumor
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Coumaric Acids / chemistry*
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Coumaric Acids / isolation & purification
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Coumaric Acids / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Ipomoea nil / chemistry*
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Neoplasms / drug therapy
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Phenols / chemistry
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Phenols / isolation & purification
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Phenols / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Seeds / chemistry
Substances
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9-(1',4'-diamino-2',3'-butanediol)-p-coumarate
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Amides
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Anti-Inflammatory Agents
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Antineoplastic Agents, Phytogenic
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Coumaric Acids
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Phenols
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Plant Extracts