Efficacy of methotrexate in the treatment of a HLA-B27-positive Japanease patient with reactive arthritis

Nihon Rinsho Meneki Gakkai Kaishi. 2010;33(5):283-5. doi: 10.2177/jsci.33.283.


We report a case of reactive arthritis in a 21-year-old man who was successfully treated with methotrexate. In July 2008, the patient experienced arthritis in the left knee 3 days after being diagnosed as having urethritis by the urology clinic. The patient was treated with loxoprofen sodium and fosfomycin calcium at an orthopedic clinic. Antibiotics induced clinical improvement of urethritis, although arthritis became worse. Even after sulphasalazine and corticosteroid were started, polyarthritis remained persistent. Finally, methtrexate was added ; thereafter, polyarthritis and elevated CRP were resolved. HLA-B270502 was positive. Methotrexate could be one of the choices for sulphasalazine-resistant reactive arthritis.

Publication types

  • Case Reports

MeSH terms

  • Arthritis, Reactive / drug therapy*
  • Arthritis, Reactive / etiology
  • Arthritis, Reactive / immunology
  • HLA-B27 Antigen / analysis*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Methotrexate / therapeutic use*
  • Urethritis / complications
  • Young Adult


  • HLA-B27 Antigen
  • Immunosuppressive Agents
  • Methotrexate