Hermann Friedberg's case report: an early description of CLOVES syndrome

Clin Genet. 2010 Oct;78(4):342-7. doi: 10.1111/j.1399-0004.2010.01479.x.


CLOVES syndrome is a recently described overgrowth disorder with complex vascular anomalies. Careful analysis of the case report by the German physician Hermann Friedberg "gigantism of the right lower limb" published in 1867 revealed that the report probably represents one of the first written accounts of CLOVES syndrome.

Publication types

  • Biography
  • Historical Article

MeSH terms

  • Abnormalities, Multiple / history
  • Bone Development
  • Female
  • Foot Deformities, Congenital / history
  • Germany
  • Gigantism / history*
  • Hand Deformities, Congenital / history
  • History, 19th Century
  • Humans
  • Musculoskeletal Abnormalities / history*
  • Scoliosis / history
  • Telangiectasis / history
  • Vascular Malformations / history*

Supplementary concepts

  • Macrodactyly of the foot
  • Macrodactyly of the hand

Personal name as subject

  • Hermann Friedberg