Abstract
Two new abietane diterpenoids, ramentoxide (1) and ramentoxidone (2) and a new icetexane diterpenoid, amentonone (3) were isolated from the barks of Amentotaxus formosana. The structures of 1-3 were determined by spectroscopic methods. Known compounds brevitaxin (4), and (+)-ferruginol (5) and ent-kaur-16-en-15-one (6) isolated from this plant revealed potent cytotoxic activity against human breast adenocarcinoma cells, MCF-7 cells with an IC(50) value of 0.08 ± 0.05 μg/mL, and significant anti-inflammatory activities, respectively.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Abietanes / isolation & purification
-
Abietanes / pharmacology
-
Abietanes / therapeutic use
-
Adenocarcinoma / drug therapy*
-
Anti-Inflammatory Agents / isolation & purification
-
Anti-Inflammatory Agents / pharmacology
-
Anti-Inflammatory Agents / therapeutic use*
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Antineoplastic Agents, Phytogenic / therapeutic use*
-
Breast Neoplasms / drug therapy*
-
Cell Line, Tumor
-
Diterpenes / isolation & purification
-
Diterpenes / pharmacology
-
Diterpenes / therapeutic use*
-
Female
-
Humans
-
Inhibitory Concentration 50
-
Lignans / isolation & purification
-
Lignans / pharmacology
-
Lignans / therapeutic use
-
Molecular Structure
-
Phytotherapy*
-
Plant Bark
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology
-
Plant Extracts / therapeutic use
-
Taxaceae / chemistry*
Substances
-
Abietanes
-
Anti-Inflammatory Agents
-
Antineoplastic Agents, Phytogenic
-
Diterpenes
-
Lignans
-
Plant Extracts
-
amentonone
-
brevitaxin
-
ferruginol
-
ramentoxide
-
ramentoxidone