Hypothalamic hamartomas and sexual precocity. Evaluation of treatment options

Am J Dis Child. 1990 Feb;144(2):225-8. doi: 10.1001/archpedi.1990.02150260105040.


We describe four male patients with hypothalamic hamartomas associated with sexual precocity. Our assessment of their management suggests that resection using current microsurgical techniques is a valid treatment option if the patient has a normal pubertal endocrine makeup, if the hamartoma is pedunculated, and if the patient is young enough to require years of parenteral medical treatment. Such surgical treatment can be curative, and subsequent growth and development can be normal (patients 1 and 2). However, if the patient is near to pubertal age (patient 3) or if neurosurgical or gonadotropin releasing hormone analogue treatment is not available, the natural history (patient 4) suggests that the only undesirable effects are accelerated growth, tall stature for age, and premature sexual development during childhood, as well as the psychosocial problems that may accompany them. Adult height may be compromised, although the two patients who did not undergo a surgical procedure and did not receive gonadotropin releasing hormone analogue therapy are above the lower limits of the normal range of adult male height. Therefore, if the hamartoma is pedunculated and cessation of pubertal development is desired, resection of the hamartoma is a reasonable therapeutic option.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Child
  • Child, Preschool
  • Danazol / therapeutic use
  • Follicle Stimulating Hormone / blood
  • Gonadotropin-Releasing Hormone / analogs & derivatives
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Hamartoma / complications*
  • Hamartoma / drug therapy
  • Hamartoma / surgery
  • Humans
  • Hypothalamic Neoplasms / complications*
  • Hypothalamic Neoplasms / drug therapy
  • Hypothalamic Neoplasms / surgery
  • Infant
  • Leuprolide
  • Luteinizing Hormone / blood
  • Male
  • Puberty, Precocious / etiology*
  • Testosterone / blood


  • Antineoplastic Agents
  • Gonadotropin-Releasing Hormone
  • Testosterone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Leuprolide
  • Danazol