Mechanosensitive channels: in touch with Piezo

Curr Biol. 2010 Nov 9;20(21):R936-8. doi: 10.1016/j.cub.2010.09.053.


Mechanosensory transduction underlies touch, hearing and proprioception and requires mechanosensitive channels that are directly gated by forces; however, the molecular identities of these channels remain largely elusive. A new study has identified Piezo1 and Piezo2 as a novel class of mechanosensitive channels.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Ion Channels / chemistry
  • Ion Channels / genetics
  • Ion Channels / physiology*
  • Mechanotransduction, Cellular / physiology*
  • Mice
  • Neurons / metabolism
  • Protein Structure, Tertiary


  • Ion Channels
  • Piezo1 protein, mouse
  • Piezo2 protein, mouse