Cleavage isn't everything: potential novel mechanisms of exfoliative toxin-mediated blistering

Am J Pathol. 2010 Dec;177(6):2682-4. doi: 10.2353/ajpath.2010.100980. Epub 2010 Nov 5.

Abstract

This Commentary describes breakthroughs in understanding the interactions between desmoglein 1 and plakogloben in staphylococcal-mediated blistering skin diseases.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Blister / etiology*
  • Blister / genetics
  • Blister / therapy
  • Desmoglein 1 / genetics
  • Desmoglein 1 / physiology
  • Exfoliatins / adverse effects*
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / etiology
  • Infant, Newborn, Diseases / genetics
  • Infant, Newborn, Diseases / therapy
  • Mice
  • Pemphigus / congenital
  • Pemphigus / etiology
  • Pemphigus / genetics
  • Pemphigus / therapy
  • Protein Processing, Post-Translational / genetics
  • Protein Processing, Post-Translational / physiology*
  • Staphylococcal Scalded Skin Syndrome / complications
  • Staphylococcal Scalded Skin Syndrome / etiology*
  • Staphylococcal Scalded Skin Syndrome / genetics
  • Staphylococcal Scalded Skin Syndrome / therapy
  • gamma Catenin / genetics
  • gamma Catenin / physiology

Substances

  • Desmoglein 1
  • Exfoliatins
  • gamma Catenin