6-Hydroxydopamine lesions of the olfactory tubercle do not alter (+)-amphetamine-conditioned place preference

Behav Brain Res. 1990 Jan 1;36(1-2):185-8. doi: 10.1016/0166-4328(90)90173-c.

Abstract

Rats received bilateral infusions of 6-hydroxydopamine into the olfactory tubercle, resulting in a substantial (89%) local depletion of dopamine. This treatment did not significantly alter conditioned place preference produced by (+)-amphetamine, suggesting that the mesolimbic dopaminergic projection to olfactory tubercle does not mediate the rewarding effects of (+)-amphetamine in rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine / pharmacology*
  • Animals
  • Brain Mapping
  • Choice Behavior / drug effects*
  • Conditioning, Classical / drug effects*
  • Dopamine / physiology
  • Hydroxydopamines / pharmacology*
  • Male
  • Motor Activity / drug effects
  • Norepinephrine / physiology
  • Nucleus Accumbens / drug effects
  • Olfactory Bulb / drug effects*
  • Olfactory Pathways / drug effects
  • Orientation / drug effects*
  • Oxidopamine
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects*

Substances

  • Hydroxydopamines
  • Receptors, Dopamine
  • Oxidopamine
  • Amphetamine
  • Dopamine
  • Norepinephrine