Abstract
Down syndrome children show a decreased avidity of the antibody response after tetanus toxoid booster vaccination at 9 years of age suggesting impaired memory B cell selection in the germinal center. Clinicians need to be aware of this ongoing subtle immunologic deficit in Down syndrome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Bacterial / blood*
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Antibody Affinity*
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B-Lymphocytes / immunology
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Child
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Child, Preschool
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Down Syndrome*
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Humans
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Immunization, Secondary*
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Tetanus Toxoid / administration & dosage
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Tetanus Toxoid / immunology*
Substances
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Antibodies, Bacterial
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Tetanus Toxoid