LRRK2 function on actin and microtubule dynamics in Parkinson disease

Commun Integr Biol. 2010 Sep;3(5):396-400. doi: 10.4161/cib.3.5.12286.


The mutations in the LRRK2 gene cause clinically typical, late-onset Parkinson disease, strengthening the idea that the familial forms of the disease represent an important tool for the study of the idiopathic forms. Despite the great effort to describe and functionally characterize the LRRK2 gene product, its physiological role remains elusive. In this article, we will discuss along with other references, our recent findings that assigned a critical role of LRRK2 protein on cytosleketal dynamics and how this direction could provide a valuable platform to further appreciate the mechanism underlying LRRK2-mediated pathophysiology of the disease.

Keywords: ERM; G2019S; LRRK2; Parkinson disease; filamentous actin; golgi apparatus; microtubule; neuronal morphogenesis; phosphorylation; tubulin.