Prooxidant/antioxidant ratio (ProAntidex) as a better index of net free radical scavenging potential

Molecules. 2010 Nov 3;15(11):7884-92. doi: 10.3390/molecules15117884.

Abstract

The antioxidant activity of several Malaysian plant extracts was analyzed simultaneously with their pro-oxidant capacity. This ratio represents an index (ProAntidex) of the net free radical scavenging ability of whole plant extracts. We observed that ethanolic extracts of Nephelium lappaceum peel, Fragaria x ananassa leaf, Lawsonia inermis leaf, Syzygium aqueum leaf and grape seed had a lower Pro-Antidex than the commercially available Emblica™ extract which is an antioxidant agent with very low pro-oxidant activity. Among the aqueous extracts, Lawsonia inermis leaf, Nephelium mutobile leaf and grape seed had lower pro-oxidant activity compared to the Emblica™ extract. Among these extracts, aqueous extract of Nephelium mutobile leaf had a very low index of 0.05 compared to 0.69 for Emblica™. Most of the extracts had a far lower ProAntidex compared to the Vitamin C. The index enables us to identify extracts with high net free radical scavenging activity potential. The ProAntidex is beneficial as a screening parameter to the food industries and healthcare.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry*
  • Fragaria / chemistry
  • Free Radical Scavengers / chemistry*
  • Lawsonia Plant / chemistry
  • Plant Extracts / chemistry*
  • Plant Leaves / chemistry
  • Reactive Oxygen Species / chemistry*
  • Seeds / chemistry
  • Vitis / chemistry

Substances

  • Antioxidants
  • Free Radical Scavengers
  • Plant Extracts
  • Reactive Oxygen Species