Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct 20;4:148.
doi: 10.3389/fnsys.2010.00148. eCollection 2010.

Studying Network Mechanisms Using Intracranial Stimulation in Epileptic Patients

Affiliations
Free PMC article

Studying Network Mechanisms Using Intracranial Stimulation in Epileptic Patients

Olivier David et al. Front Syst Neurosci. .
Free PMC article

Abstract

Patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes allow to obtain data of exceptional value for studying brain dynamics in correlation with pathophysiological and cognitive processes. Direct electrical stimulation (DES) of cortical regions and axonal tracts in those patients elicits a number of very specific perceptual or behavioral responses, but also abnormal responses due to specific configurations of epileptic networks. Here, we review how anatomo-functional brain connectivity and epilepsy network mechanisms can be assessed from DES responses measured in patients. After a brief summary of mechanisms of action of brain electrical stimulation, we recall the conceptual framework for interpreting DES results in the context of brain connectivity and review how DES can be used for the characterization of functional networks, the identification of the seizure onset zone, the study of brain plasticity mechanisms, and the anticipation of epileptic seizures. This pool of exceptional data may be underexploited by fundamental research on brain connectivity and leaves much to be learned.

Keywords: cognition; connectivity; electroencephalography; epilepsy; networks; neurostimulation; plasticity.

Similar articles

See all similar articles

Cited by 18 articles

See all "Cited by" articles

References

    1. Afif A., Hoffmann D., Minotti L., Benabid A. L., Kahane P. (2008). Middle short gyrus of the insula implicated in pain processing. Pain 138, 546–555 - PubMed
    1. Afif A., Minotti L., Kahane P., Hoffmann D. (2010). Middle short gyrus of the insula implicated in speech production: intracerebral electric stimulation of patients with epilepsy. Epilepsia 51, 206–21310.1111/j.1528-1167.2009.02271.x - DOI - PubMed
    1. Barbeau E., Wendling F., Regis J., Duncan R., Poncet M., Chauvel P., Bartolomei F. (2005). Recollection of vivid memories after perirhinal region stimulations: synchronization in the theta range of spatially distributed brain areas. Neuropsychologia 43, 1329–133710.1016/j.neuropsychologia.2004.11.025 - DOI - PubMed
    1. Behrens T. E., Johansen-Berg H., Woolrich M. W., Smith S. M., Wheeler-Kingshott C. A., Boulby P. A., Barker G. J., Sillery E. L., Sheehan K., Ciccarelli O., Thompson A. J., Brady J. M., Matthews P. M. (2003). Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat. Neurosci. 6, 750–75710.1038/nn1075 - DOI - PubMed
    1. Bernier G. P., Saint-Hilaire J. M., Giard N., Bouvier G., Mercier M. (1987). “Commentary: intracranial electrical stimulation,” in Surgical Treatment of the Epilepsies, ed. Engel J. Jr., editor. (New York:Raven Press; ), 323–334 - PubMed
Feedback