Abstract
The concise total synthesis of largazole was accomplished. The key step included the use of the Nagao thiazolidinethione auxiliary for the diastereoselective acetate aldol reaction and it acts as an acylating agent for the peptide formation.
MeSH terms
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Catalysis
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Depsipeptides / chemical synthesis*
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Depsipeptides / chemistry
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Thiazoles / chemical synthesis*
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Thiazoles / chemistry
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Thiazolidines / chemistry*
Substances
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Depsipeptides
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Thiazoles
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Thiazolidines
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largazole
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thiazoline-2-thione