Lycopodium alkaloids from Huperzia serrata

J Asian Nat Prod Res. 2010 Nov;12(11):1005-9. doi: 10.1080/10286020.2010.522180.

Abstract

A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkaloid for the first time, and showed an antagonist effect on the N-methyl-d-aspartate receptor with an IC(50) value of 0.92 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Cerebral Cortex / drug effects
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Huperzia / chemistry*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Synaptic Membranes / drug effects

Substances

  • 12-deoxyhuperzine O
  • 6-hydroxy-5,15-oxide-lycopodane
  • Alkaloids
  • Drugs, Chinese Herbal
  • Receptors, N-Methyl-D-Aspartate