Dendritic Cells and T Cells in Immunotherapy

J Drugs Dermatol. 2010 Nov;9(11):1383-92.

Abstract

Autologous cellular immunotherapies have been used experimentally in humans to treat many types of cancer. These therapies are divided into two principal types: active cellular immunotherapies that rely on autologous dendritic cells or other antigen presenting cells; and adoptive T-cell therapies, in which large numbers of antigen-specific T lymphocytes are propagated ex vivo and then infused back into the patient. With the FDA approval of the antigen presenting cell vaccine sipuleucel-T for prostate cancer, active immunization has become an accepted approach for the treatment of established cancer.

Publication types

  • Review

MeSH terms

  • Adoptive Transfer
  • Animals
  • Antigen-Presenting Cells / immunology
  • Cancer Vaccines / immunology
  • Cancer Vaccines / therapeutic use*
  • Dendritic Cells / immunology*
  • Humans
  • Immunotherapy*
  • Male
  • Prostatic Neoplasms / therapy
  • T-Lymphocytes / immunology*
  • Tissue Extracts / immunology
  • Tissue Extracts / therapeutic use*

Substances

  • Cancer Vaccines
  • Tissue Extracts
  • sipuleucel-T