Purpose: To discuss the common characteristics of infants and children with nystagmus and review treatments and their evidence.
Methods: The NEI-sponsored classification of eye movement abnormalities and strabismus and a PubMed search for papers from 1995 through 2005 on interventions for Infantile Nystagmus Syndrome (INS) are reviewed.
Results: The review of treatments revealed 18 papers on surgical or pharmacological interventions and six papers describing other interventions. There is only one randomized controlled trial, with all the other studies being uncontrolled trials/case series.
Conclusions: Previous science and studies on interventions for nystagmus in infancy and childhood have laid an important foundation for future work in this field, which should include a randomized clinical trial.