Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity

J Antibiot (Tokyo). 1990 Jan;43(1):8-18. doi: 10.7164/antibiotics.43.8.

Abstract

Streptomyces hygroscopicus No. P247-71(ATCC 53709)produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L- serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.

MeSH terms

  • Amides / isolation & purification
  • Amides / pharmacology
  • Animals
  • Antibiotics, Antineoplastic / biosynthesis*
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology
  • DNA, Neoplasm / biosynthesis
  • Fermentation
  • Humans
  • Leukemia L1210 / drug therapy
  • Leukemia P388 / drug therapy
  • Melanoma, Experimental / drug therapy*
  • Mice
  • Molecular Structure
  • RNA, Neoplasm / biosynthesis
  • Serine / analogs & derivatives
  • Serine / isolation & purification
  • Serine / pharmacology
  • Streptomyces / metabolism*
  • Tumor Cells, Cultured

Substances

  • Amides
  • Antibiotics, Antineoplastic
  • DNA, Neoplasm
  • RNA, Neoplasm
  • eponemycin
  • Serine