Microperimetry and OCT findings in female carriers of choroideremia

Ophthalmic Genet. 2010 Dec;31(4):235-9. doi: 10.3109/13816810.2010.518578.


Purpose: To evaluate structural retinal changes and macular function by a combined spectral domain optical coherence tomography/scanning laser ophthalmoscope (OCT/SLO) microperimetry device in choroideremia carriers.

Methods and materials: Ten choroideremia carriers were included in the study. All subjects had a complete ophthalmic examination in addition to Goldmann kinetic visual fields, OCT and microperimetry testing on a commercially available Spectral Domain (SD) OCT/SLO combination system.

Results: Microperimetry results demonstrated focal areas of threshold abnormalities in 50% of the subjects. OCT findings show subtle retinal pigment epithelium (RPE) irregularities with attenuation more pronounced outside the macular region.

Conclusions: Long term follow up with microperimetric testing could be useful in monitoring any progressive loss of retinal function in choroideremia carriers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Choroideremia / diagnosis*
  • Choroideremia / genetics*
  • Female
  • Heterozygote
  • Humans
  • Middle Aged
  • Ophthalmoscopy
  • Retina / pathology*
  • Tomography, Optical Coherence*
  • Visual Acuity
  • Visual Field Tests*
  • Visual Fields*
  • Young Adult