Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells

Kana Suou; Fuminori Taniguchi; Yukiko Tagashira; Tomoiki Kiyama; Naoki Terakawa; Tasuku Harada

doi:10.1016/j.fertnstert.2010.09.046

Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells

Fertil Steril. 2011 Mar 15;95(4):1518-21. doi: 10.1016/j.fertnstert.2010.09.046. Epub 2010 Nov 10.

Authors

Kana Suou¹, Fuminori Taniguchi, Yukiko Tagashira, Tomoiki Kiyama, Naoki Terakawa, Tasuku Harada

Affiliation

¹ Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.

PMID: 21067731
DOI: 10.1016/j.fertnstert.2010.09.046

Abstract

Apigenin suppressed tumor necrosis factor α-induced cell proliferation and prostaglandin E2 expression via the attenuation of nuclear factor κB pathway in endometriotic stromal cells in vitro. Apigenin reduced the mitogenic activity and inflammatory reaction in endometriotic stromal cells.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Apigenin / pharmacology*
Cell Proliferation / drug effects
Cells, Cultured
Dinoprostone / antagonists & inhibitors*
Dinoprostone / biosynthesis
Endometrium / cytology*
Endometrium / drug effects*
Endometrium / metabolism
Female
Growth Inhibitors / physiology*
Humans
NF-kappa B / antagonists & inhibitors*
NF-kappa B / physiology
Stromal Cells / cytology
Stromal Cells / drug effects
Stromal Cells / metabolism
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Tumor Necrosis Factor-alpha / metabolism

Substances

Growth Inhibitors
NF-kappa B
Tumor Necrosis Factor-alpha
Apigenin
Dinoprostone