Abstract
We identified 12 erythromycin- and clindamycin-resistant emm 90 group A streptococcus (GAS) isolates during a retrospective invasive disease survey in Hawaii. A comparison with 20 type-matched isolates showed all resistant isolates to be emm 90.4b with the constitutive or inducible macrolide-lincosamide-streptogramin B resistance phenotype (cMLS(B) or iMLS(B)). All isolates had the same pulsed-field gel electrophoresis (PFGE) pattern, suggesting clonal spread.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Typing Techniques
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Clindamycin / pharmacology*
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Drug Resistance, Bacterial*
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Electrophoresis, Gel, Pulsed-Field
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Erythromycin / pharmacology*
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Gene Expression Regulation, Bacterial
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Genotype
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Hawaii
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Humans
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Molecular Typing
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Retrospective Studies
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Streptococcal Infections / microbiology*
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Streptococcus pyogenes / classification
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Streptococcus pyogenes / drug effects*
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Streptococcus pyogenes / isolation & purification*
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Streptogramin B / pharmacology
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Transcriptional Activation
Substances
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Anti-Bacterial Agents
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Streptogramin B
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Clindamycin
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Erythromycin