Emergence of erythromycin- and clindamycin-resistant Streptococcus pyogenes emm 90 strains in Hawaii

J Clin Microbiol. 2011 Jan;49(1):439-41. doi: 10.1128/JCM.02208-10. Epub 2010 Nov 10.

Abstract

We identified 12 erythromycin- and clindamycin-resistant emm 90 group A streptococcus (GAS) isolates during a retrospective invasive disease survey in Hawaii. A comparison with 20 type-matched isolates showed all resistant isolates to be emm 90.4b with the constitutive or inducible macrolide-lincosamide-streptogramin B resistance phenotype (cMLS(B) or iMLS(B)). All isolates had the same pulsed-field gel electrophoresis (PFGE) pattern, suggesting clonal spread.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Typing Techniques
  • Clindamycin / pharmacology*
  • Drug Resistance, Bacterial*
  • Electrophoresis, Gel, Pulsed-Field
  • Erythromycin / pharmacology*
  • Gene Expression Regulation, Bacterial
  • Genotype
  • Hawaii
  • Humans
  • Molecular Typing
  • Retrospective Studies
  • Streptococcal Infections / microbiology*
  • Streptococcus pyogenes / classification
  • Streptococcus pyogenes / drug effects*
  • Streptococcus pyogenes / isolation & purification*
  • Streptogramin B / pharmacology
  • Transcriptional Activation

Substances

  • Anti-Bacterial Agents
  • Streptogramin B
  • Clindamycin
  • Erythromycin