Effective--a database of predicted secreted bacterial proteins

Nucleic Acids Res. 2011 Jan;39(Database issue):D591-5. doi: 10.1093/nar/gkq1154. Epub 2010 Nov 11.


Protein secretion is a key virulence mechanism of pathogenic and symbiotic bacteria, which makes the investigation of secreted proteins ('effectors') crucial for understanding the molecular bacterium-host interactions. Effective (http://effectors.org) is a database of predicted bacterial secreted proteins, implementing two complementary prediction strategies for protein secretion: the identification of eukaryotic-like protein domains and the recognition of signal peptides in amino acid sequences. The Effective web portal provides user-friendly tools for browsing and retrieving comprehensive precalculated predictions for whole bacterial genomes as well as for the interactive prediction of effectors in user-provided protein sequences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Databases, Protein*
  • Genome, Bacterial
  • Protein Sorting Signals
  • Protein Structure, Tertiary


  • Bacterial Proteins
  • Protein Sorting Signals