Improved visual hallucination by donepezil and occipital glucose metabolism in dementia with Lewy bodies: the Osaki-Tajiri project

Eur Neurol. 2010;64(6):337-44. doi: 10.1159/000322121. Epub 2010 Nov 13.


Deficits in the cholinergic system are pronounced in dementia with Lewy bodies (DLB) and are more severe in patients with visual hallucinations (VHs). The aim is to identify the occipital glucose metabolism patterns by positron emission tomography (PET) and the changes following donepezil treatment. 13 DLB patients with VHs were enrolled in the study. After the first FDG-PET study, 5 mg/day donepezil was administered orally, and a second PET study was performed 3 months later. After donepezil administration, VHs disappeared completely in 6 patients, and the PET studies revealed significantly decreased glucose metabolism in the medial occipital cortex. These results suggest that VHs in DLB were associated with impaired glucose metabolism in the medial occipital cortex. Donepezil treatment may modify regional glucose metabolism.

Publication types

  • Clinical Trial

MeSH terms

  • Aged, 80 and over
  • Donepezil
  • Female
  • Glucose / metabolism*
  • Hallucinations / complications
  • Hallucinations / drug therapy*
  • Hallucinations / etiology
  • Humans
  • Image Interpretation, Computer-Assisted
  • Indans / therapeutic use*
  • Lewy Body Disease / complications
  • Lewy Body Disease / diagnostic imaging
  • Lewy Body Disease / drug therapy*
  • Lewy Body Disease / metabolism
  • Male
  • Neuropsychological Tests
  • Nootropic Agents / therapeutic use*
  • Occipital Lobe / diagnostic imaging
  • Occipital Lobe / drug effects
  • Occipital Lobe / metabolism*
  • Piperidines / therapeutic use*
  • Positron-Emission Tomography


  • Indans
  • Nootropic Agents
  • Piperidines
  • Donepezil
  • Glucose