Genetic disorders of glomerular basement membranes

Nephron Clin Pract. 2011;118(1):c9-c18. doi: 10.1159/000320876. Epub 2010 Nov 11.


This review provides current information about glomerular disorders that arise directly from inherited abnormalities in extracellular matrix proteins intrinsic to the glomerular basement membrane (Alport syndrome, thin basement membrane nephropathy, HANAC syndrome and Pierson syndrome). The authors also discuss disorders involving genetic defects in cellular proteins that result in structural defects in glomerular basement membranes (MYH9-related disorders, nail-patella syndrome).

Publication types

  • Review

MeSH terms

  • Animals
  • Genetic Predisposition to Disease / genetics*
  • Glomerular Basement Membrane / physiopathology*
  • Humans
  • Kidney / physiopathology*
  • Kidney Diseases / genetics*