Analysis of HIV Tropism in Ugandan Infants

Curr HIV Res. 2010 Oct;8(7):498-503. doi: 10.2174/157016210793499187.

Abstract

HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / therapeutic use
  • CD4 Antigens
  • Cells, Cultured
  • HIV / physiology*
  • HIV Infections / drug therapy
  • HIV Infections / mortality
  • HIV Infections / virology*
  • Humans
  • Infant
  • Infant, Newborn
  • Receptors, CCR5 / metabolism
  • Receptors, CXCR4 / metabolism
  • Survival
  • Uganda
  • Viral Tropism*

Substances

  • Anti-HIV Agents
  • CD4 Antigens
  • Receptors, CCR5
  • Receptors, CXCR4